The Washington DC road’s name is a nod to the title of a book and film about the lives of Katherine Johnson, Dorothy Vaughan, and Mary Jackson.
They made significant contributions to space flight during the 1960s.
In any case, their victories and battles were not broadly known until some other time.
“‘Hidden Figures’ is about taking off our blinders and recognising the contributions of the unseen individuals who were there at the beginning of the story,” Margot Lee Shetterly, who wrote the 2016 book which inspired the Oscar-nominated film, told the audience gathered in Washington.
“And whose persistence and whose courage delivered us to where we are today.”
Ms Shetterly went to the disclosing of the road sign alongside individuals from every woman’s family.
Republican Senator Ted Cruz, who cosponsored a bill to rename the square, said he trusted the name would rouse who and what is to come.
Republican Senator Ted Cruz, who cosponsored a bill to rename the block, said he hoped the name would inspire future generations.
“When little girls and little boys come to see NASA, they’re going to look up and see that sign,” he said.
“This sign is a powerful testament that anyone who is telling a little girl or a little boy ‘You can’t do something’, is not telling the truth.”
Nasa started selecting some school instructed African American women during the 1940s as “human computers”, however they encountered both racial and gender discrimination at work.
The renaming of the street comes in front of 50th anniversary of the first moonwalk by NASA astronauts on 20 July.
Nasa as of late declared it would send Americans back to the moon by 2024, including the first woman to walk on its surface.
Fewer than 11% of the 500-plus people who have travelled to space have been women, the space agency said.